제목

Effects of Brown Rice Diets Inoculated with Lactobacillus sakei Wikim001 Having Phytase Activity on the Osteoporosis in Ovariectomized Mice Model

요약

 The present study examined the preventive effect of osteoporosis in ovariectomized (OVX) mice by feeding of phytate-reduced brown rice inoculated with the selected Lactobacillus sakei Wikim001 having high phytase activity. Contrary to 5% BR-WK diet, OVX mice with normal diet containing 10% brown rice manufactured with L. sakei Wikim001 (10 % BR-WK diet) exhibited the increase of trabecular bone volume/tissue volume, bone surface/tissue volume, trabecular number, and bone mineral density in femur as compared with the control OVX mice. Moreover, OVX mice fed with 10% BR-WK diet decreased bone turnover markers, including osteocalcin and CTX-1. These results suggest that BR-WK diet has a bone sparing effect in OVX-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing bone turnover rate. Therefore, BR-WK diet may be useful for preserving bone mass and structure against osteoporosis.